Zoe Williams 

Could a drug for narcolepsy change the world?

There are apparently breakthroughs on the way for those with sleep disorders – which sent me down a rabbit hole of research, writes Zoe Williams
  
  

Woman with eyes closed on train
‘It’s only because we find each other so interesting that any of us are awake at all.’ Photograph: Posed by model; Westend61/Getty Images

I met a guy in pharmaceuticals who told me about a bunch of cool breakthroughs in sleep meds: mainly, we may be on the brink of a new Wegovy, but in this case it’s a drug to cure narcolepsy. I suggested the two things are not quite the same, given that obesity is a global epidemic and narcolepsy is fairly rare. He countered that the way the drug works might also have applications for insomnia; similar to the Post-it note having been invented by someone trying to create the world’s strongest glue.

Anyway, in the course of this, I discovered the test for type 1 narcolepsy, which is that you’re put in a room with zero stimulation – nothing to read, no one to chat to, perfect silence, perfect temperature – and timed on how long it takes you to fall asleep. If it’s under eight minutes, you’re narcoleptic. But the average, for a person with no complaints in that area at all, is 22 minutes. I was completely incredulous. This is a grip on consciousness more or less the same as a house cat. Bored? Go to sleep. Even a dog will have a quick look for something to eat first.

Obviously I’ve spread this troubling statistic all over town, and most people have follow-ups, such as: what kind of a room? What colour is the room? Is there a chair in it, and is it comfy? Never mind the chair, what kind of hoodlum can fall asleep without a bed?

I also discovered cataplexy, which can involve falling asleep after strong emotions, not necessarily bad ones (laughing too hard is a trigger), and strongly recognised it. Sometimes I go to sleep on the tube just because I’m pleased the tube has arrived.

In short, science has delivered a fresh wonder. It’s only because we find each other so interesting that any of us are awake at all.

• Zoe Williams is a Guardian columnist

 

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